Subinhibitory concentrations of β-lactam induce haemolytic activity inStaphylococcus aureusthrough the SaeRS two-component system
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منابع مشابه
The SaeRS Two-Component System of Staphylococcus aureus
In the Gram-positive pathogenic bacterium Staphylococcus aureus, the SaeRS twocomponent system (TCS) plays a major role in controlling the production of over 20 virulence factors including hemolysins, leukocidins, superantigens, surface proteins, and proteases. The SaeRS TCS is composed of the sensor histidine kinase SaeS, response regulator SaeR, and two auxiliary proteins SaeP and SaeQ. Since...
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Calprotectin, the most abundant cytoplasmic protein in neutrophils, suppresses the growth of Staphylococcus aureus by sequestering the nutrient metal ions Zn and Mn. Here we show that calprotectin can also enhance the activity of the SaeRS two component system (TCS), a signaling system essential for production of over 20 virulence factors in S. aureus. The activity of the SaeRS TCS is repressed...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 2007
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.2006.00568.x